Article: Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Power JM; Wu WW; Sametsky E; Oh MM; Disterhoft JF J. Neurosci., 2002
Young | Aging | pvalues | |||||||
---|---|---|---|---|---|---|---|---|---|
Mean | SEM | n | Mean | SEM | n | T | F | U | |
Post-burst AHP measures | |||||||||
Amplitude (mV) | −7.21 | 0.45 | 15 | −9.03 | 0.64 | 12 | 0.025 | 0.395 | |
Area (mV msec) | −11344 | 1588 | 15 | −14106 | 1732 | 12 | 0.252 | ||
Duration (msec) | 5489 | 622 | 15 | 6009 | 636 | 12 | 0.568 | ||
Latency (msec) | 96.6 | 20.4 | 15 | 55.5 | 9.7 | 12 | 0.006 | 0.242 | |
AHP tail current measures | |||||||||
Peak amplitude (pA) | 374.1 | 36.3 | 18 | 604.7 | 66.2 | 16 | 0.037 | 0.007 | |
Latency to peak amplitude (msec) | 154.9 | 39.2 | 18 | 92.4 | 26.1 | 16 | 0.205 | ||
Area (pC) | 468.9 | 57.8 | 17 | 830.8 | 111.2 | 16 | 0.019 | 0.012 | |
200 msec amplitude (pA) | 321.6 | 32.9 | 18 | 486.2 | 47.0 | 16 | 0.006 | 0.247 | |
1 sec amplitude (pA) | 186.8 | 22.8 | 18 | 325.9 | 39.5 | 16 | 0.004 | 0.059 | 0.006 |
2 sec amplitude (pA) | 101.3 | 16.4 | 18 | 206.2 | 30.9 | 16 | 0.027 | 0.006 | |
Decay tau (msec) | −1814 | 141 | 16 | −2122 | 183 | 16 | 0.193 | ||
200 half decay (msec) | 1256 | 127 | 18 | 1559 | 138 | 16 | 0.117 | ||
800 half decay (msec) | 1801 | 96 | 18 | 2141 | 92 | 16 | 0.016 | 0.684 | |
Reversal potential (mV) | −93.88 | 2.53 | 7 | −93.66 | 1.94 | 11 | 0.944 | ||
Membrane resistance (MΩ) | 101.11 | 5.87 | 18 | 103.06 | 6.79 | 16 | 0.828 | ||
Resting potential (mV) | −70.19 | 1.41 | 20 | −75.87 | 1.23 | 16 | 0.006 | 0.307 |
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The mean, SEM, and number of neurons recorded (n) are given for young and aging neurons. Age-related comparisons were performed using unpaired t test (T), F test (F), and Mann-Whitney U test (U) as appropriate. Significant effects are highlighted in bold.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Hippocampus CA1 pyramidal cell | cell surface area | -11344.0 | -- | Data Table | |
Hippocampus CA1 pyramidal cell | resting membrane potential (mV) | -70.19 | -- | Data Table | |
Hippocampus CA1 pyramidal cell | spike width (msec) | 5489.0 | -- | Data Table | |
Hippocampus CA1 pyramidal cell | spike amplitude (mV) | -7.21 | -- | Data Table | |
Hippocampus CA1 pyramidal cell | AHP amplitude (pA) | 374.1 | -- | Data Table | |
Hippocampus CA1 pyramidal cell | AHP amplitude (msec) | 154.9 | -- | Data Table | |
Hippocampus CA1 pyramidal cell | cell surface area (pC) | 468.9 | -- | Data Table |